Surgical management of brain metastases

Metastatic brain tumors are the most common intracranial tumors in adults and the most common cause of neurologic morbidity and mortality in these patients. Recent advances in the management of the primary cancer have resulted in improved prognosis, longer survival, and thus, increased identification of the presence of brain metastases. Data suggest that aggressive treatment of the metastatic brain tumor with surgical resection increases the length of survival in these patients. New techniques, including preoperative functional imaging, stereotactic surgical resection, image-guided neurosurgery, intraoperative ultrasound, and cortical mapping, have aided neurosurgeons in surgical resection and have helped to lower the associated surgical morbidity and mortality. The respective roles of surgery, patient selection, prognostic factors, and radiotherapy are addressed in this review.