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Significant overexpression of oligophrenin-1 in colorectal tumors detected by cDNA microarray analysis
N A Pinheiro1, O L Caballero, F Soares
1Department of Biochemistry, Instituto de Química, University of São Paulo, São Paulo, Brazil.
Cancer Letters
|October 12, 2001
Abstract:
The human oligophrenin-1 gene is ubiquitously expressed at low levels and expressed at high levels in the developing neuroepithelium of the neural tube. Mutations in this gene have been related to the X-linked mental retardation. Using cDNA microarrays, we found evidence that oligophrenin-1 is strongly up-regulated in colorectal tumors. Semiquantitative reverse transcriptase polymerase chain reaction confirmed this finding. Thus, a well-known nervous system-associated human gene transcript may also be an important colorectal tumor marker and potential therapeutic target.