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Temporal relationship of generalized epileptiform discharges to spindle frequency activity in childhood absence
L Nobili1, M G Baglietto, M Beelke
1Centro di Medicina del Sonno, Catterdra di Neurofisiopatologia, Università di Genova, Ospedale San Martino, Largo R. Benzi 10, 16132, Genoa, Italy.
Objective:
The hypothesis that the two main synchronizing mechanisms (spindle and delta oscillations) acting during non-rapid eye movement sleep show opposite relationship with the distribution of generalized epileptiform discharges (GEDs) during sleep was evaluated.
Methods:
We studied the temporal relationship between the distribution of sleep GEDs and the dynamics of Sigma Activity (SA, 12-16 Hz) and Delta Activity (DA, 0.5-4.5 Hz) in 5 children affected by childhood absence epilepsy.
Results:
Using correlation techniques, we found a high and positive correlation between GEDs and SA, while DA resulted negatively correlated with GEDs.
Conclusion:
Sleep generalized spike-and-slow-waves seems to be produced when spindle synchronizing mechanisms are active while DA production seem to exert an inhibiting role. Such a feature seems to be common to other childhood partial and undetermined epileptic syndromes.