Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Correlation between hippocampal BDNF mRNA expression and memory performance in senescent rats.

M J Schaaf1, J O Workel, H M Lesscher

  • 1Leiden/Amsterdam Center for Drug Research, Division of Medical Pharmacology, Sylvius Laboratories. P.O. Box 9503, 2300 RA, Leiden, The Netherlands. schaaf@niehs.nih.gov

Brain Research
|October 12, 2001
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Science with Seymour Levine: on glucocorticoid action from birth to senescence.

Neurobiology of stress·2026
Same author

Effects of the mineralocorticoid receptor antagonist eplerenone in experimental autoimmune encephalomyelitis.

The Journal of steroid biochemistry and molecular biology·2024
Same author

Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation.

Frontiers in neuroendocrinology·2018
Same author

Mineralocorticoid receptor associates with pro-inflammatory bias in the hippocampus of spontaneously hypertensive rats.

Journal of neuroendocrinology·2017
Same author

Coping with the Forced Swim Stressor: Towards Understanding an Adaptive Mechanism.

Neural plasticity·2016
Same author

Isoform switching of steroid receptor co-activator-1 attenuates glucocorticoid-induced anxiogenic amygdala CRH expression.

Molecular psychiatry·2016

Brain-derived neurotrophic factor (BDNF) influences memory. Senescent rats with better spatial memory showed higher hippocampal BDNF mRNA levels after training, indicating BDNF

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Gerontology

Background:

  • Brain-derived neurotrophic factor (BDNF) is implicated in memory functions.
  • Early life stress can impact cognitive function and BDNF expression later in life.
  • Senescence is associated with cognitive decline and changes in neurotrophic factors.

Purpose of the Study:

  • To investigate the association between memory impairment in senescence and hippocampal BDNF expression.
  • To compare BDNF mRNA levels in non-impaired versus impaired senescent rats after spatial learning tasks.

Main Methods:

  • Utilized 30-32-month-old Brown Norway rats with a history of maternal deprivation.
  • Assessed spatial learning ability using the Morris water maze.
  • Quantified hippocampal BDNF mRNA expression post-training and at basal levels using RT-qPCR.

Related Experiment Videos

Main Results:

  • Non-impaired rats exhibited higher post-training BDNF mRNA levels in the CA1 region compared to impaired rats.
  • Non-impaired rats showed increased BDNF mRNA in CA1 and dentate gyrus post-training relative to basal levels.
  • Impaired rats did not show significant changes in hippocampal BDNF mRNA levels after training.

Conclusions:

  • Hippocampal BDNF expression in response to spatial training is associated with memory performance in senescent rats.
  • BDNF upregulation following learning tasks may be crucial for maintaining cognitive function during aging.
  • Early life stress may alter the relationship between BDNF and memory in aged individuals.