Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Na channel kinetics: developing models from non-stationary current fluctuations by analytic methods.

C Blomberg1, F Elinder, P Arhem

  • 1Department of Theoretical Physics, Royal Institute of Technology, SE-100 44 Stockholm, Sweden. cob@theophys.kth.se

Bio Systems
|October 12, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neural inhibition can explain negative BOLD responses: A mechanistic modelling and fMRI study.

NeuroImage·2017
Same author

Isopimaric acid - a multi-targeting ion channel modulator reducing excitability and arrhythmicity in a spontaneously beating mouse atrial cell line.

Acta physiologica (Oxford, England)·2017
Same author

Polyunsaturated fatty acids are potent openers of human M-channels expressed in Xenopus laevis oocytes.

Acta physiologica (Oxford, England)·2016
Same author

The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the σ-1 receptor.

Molecular psychiatry·2012
Same author

Pattern of accessory regions and invasive disease potential in Streptococcus pneumoniae.

The Journal of infectious diseases·2009
Same author

Role of cooperativity in protein folding and protein mosaic assemblage relevance for protein conformational diseases.

Current protein & peptide science·2007

This study refines sodium channel models in frog axons. Analytical methods reveal inactivation from closed states and slow recovery from open states, aligning with previous minimal model findings.

Area of Science:

  • Neuroscience
  • Biophysics
  • Computational Biology

Background:

  • Previous research analyzed sodium (Na) current fluctuations in Xenopus laevis myelinated axons.
  • Published Na channel models failed to explain experimental fluctuation data.

Purpose of the Study:

  • To extend previous analysis by specifying possible models explaining experimental data using analytical methods.
  • To derive general relations between experimental data and rate constants of one-open-state models.

Main Methods:

  • Analysis of Na current fluctuations using covariance functions under voltage clamp.
  • Stochastic simulations of published Na channel models.
  • Analytical derivation of relations between experimental data and rate constants.

Related Experiment Videos

Main Results:

  • A novel minimal Na channel model was previously developed to explain experimental results.
  • The current study analytically specifies models consistent with experimental data.
  • Identified models feature inactivation from the first closed state and slow backward rates from the open state.

Conclusions:

  • The derived analytical models align with the minimal model from previous stochastic simulations.
  • These findings provide a more detailed understanding of Na channel kinetics in myelinated axons.