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Related Concept Videos

Lateralization01:28

Lateralization

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Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
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Cerebral Hemispheres01:05

Cerebral Hemispheres

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The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
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Related Experiment Video

Updated: Feb 28, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
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Language lateralization in schizophrenia, an fMRI study.

I E Sommer1, N F Ramsey, R S Kahn

  • 1Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands. i.sommer@azu.nl

Schizophrenia Research
|October 12, 2001
PubMed
Summary
This summary is machine-generated.

Schizophrenia patients show reduced language lateralization, with increased right hemisphere activity, not decreased left hemisphere activity. This may stem from impaired right-hemisphere inhibition and is linked to more severe hallucinations.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Cerebral asymmetry is reduced in schizophrenia, impacting functional lateralization.
  • Previous studies suggest reduced functional asymmetry in schizophrenia, but the underlying hemispheric language processing remains unclear.

Purpose of the Study:

  • To investigate hemispheric dominance for language processing in schizophrenia using functional MRI.
  • To determine if reduced lateralization results from decreased left hemisphere activity or increased right hemisphere activity.

Main Methods:

  • Functional MRI (fMRI) was used to scan 12 schizophrenic patients and 12 healthy controls.
  • Participants performed verb-generation and semantic decision tasks while brain activation was measured.
  • A laterality index was calculated based on activation in frontal, temporal, and temporo-parietal language areas.

Main Results:

  • Schizophrenic patients exhibited significantly less language lateralization (mean laterality index 0.35) compared to controls (0.63).
  • Increased activation was observed in the right hemisphere language areas of patients, with no evidence of reduced left hemisphere activity.
  • Decreased language lateralization correlated with increased severity of hallucinations in patients.

Conclusions:

  • Language processing in schizophrenia is characterized by reduced lateralization, primarily due to increased right hemisphere engagement.
  • The findings suggest a potential failure in right-hemisphere inhibition contributes to altered language processing in schizophrenia.
  • Reduced language lateralization is associated with specific clinical symptoms, such as hallucinations.