Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Studies on dopaminergic and GABAergic markers in striatum reveals a decrease in the dopamine transporter in

B Dean1, T Hussain

  • 1The Rebecca Cooper Research Laboratories, The Division of Molecular Schizophrenia, The Mental Health Research Institute, Victoria, 3052, Parkville, Australia. b.dean@papyrus.mhri.edu.au

Schizophrenia Research
|October 12, 2001
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Common calcaneal tendon repair in cats: outcomes and complications associated with different postoperative tarsocrural joint immobilisation methods.

The Journal of small animal practice·2025
Same author

Observation of a Vector Charmoniumlike State at 4.7  GeV/c^{2} and Search for Z_{cs} in e^{+}e^{-}→K^{+}K^{-}J/ψ.

Physical review letters·2023
Same author

Measurement of Energy-Dependent Pair-Production Cross Section and Electromagnetic Form Factors of a Charmed Baryon.

Physical review letters·2023
Same author

Test of CP Symmetry in Hyperon to Neutron Decays.

Physical review letters·2023
Same author

Precise Measurement of the e^{+}e^{-}→D_{s}^{*+}D_{s}^{*-} Cross Sections at Center-of-Mass Energies from Threshold to 4.95 GeV.

Physical review letters·2023
Same author

Determination of Spin-Parity Quantum Numbers for the Narrow Structure near the pΛ[over ¯] Threshold in e^{+}e^{-}→pK^{-}Λ[over ¯]+c.c.

Physical review letters·2023

Schizophrenia research reveals reduced dopamine transporters in the striatum, but no direct link between dopamine and GABA system interactions. Findings suggest dopamine transporter changes may play a role in schizophrenia pathology.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Molecular Biology

Background:

  • The interaction between dopaminergic and GABAergic systems in the striatum is implicated in schizophrenia.
  • Previous hypotheses suggest that pathological changes in schizophrenia involve inter-related alterations in these systems.

Purpose of the Study:

  • To investigate changes in dopaminergic and GABAergic markers in the striatum of individuals with schizophrenia.
  • To test the hypothesis that altered interactions between dopamine and GABA systems contribute to schizophrenia.

Main Methods:

  • Post-mortem striatal tissue from schizophrenic and non-schizophrenic subjects was analyzed.
  • Key markers of dopaminergic and GABAergic neurons were quantified, including dopamine transporter, nitric oxide synthase, and various dopamine and GABA receptors.

Related Experiment Videos

Main Results:

  • A significant decrease in dopamine transporter density was observed in subjects with schizophrenia (P=0.01).
  • No significant differences were found in nitric oxide synthase, dopamine D(2)-like, D(1)-like, D(3), or GABA(A) receptors.
  • No inter-related changes were detected between dopaminergic and GABAergic markers.
  • In schizophrenic subjects, dopamine D(1)-like receptor density decreased with age and correlated positively with dopamine D(2)-like receptor density.

Conclusions:

  • The study does not strongly support the hypothesis that altered dopamine-GABA system interactions in the striatum are central to schizophrenia pathology.
  • Findings suggest that changes in the dopamine transporter within the striatum may be involved in the illness, potentially due to reduced transporter numbers or neuronal loss.