Related Experiment Video
Updated: Aug 15, 2026

Axonal Transport of Organelles in Motor Neuron Cultures using Microfluidic Chambers System
Published on: May 5, 2020
Linkers, packages and pathways: new concepts in axonal transport
A Almenar-Queralt1, L S Goldstein
1Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0683, USA.
Abstract:
The molecular mechanisms that generate efficient and directed transport of proteins and organelles in axons remain poorly understood. In the past year, many studies have identified specific transmembrane or scaffold proteins that might link motor proteins to their cargoes. These studies have also identified previously unsuspected pathways and raised the intriguing possibility that pre-packaged groups of functionally related proteins are transported together in the axon. Evidence suggests that fast molecular motor proteins have a role in slow axonal transport, and the axonal transport machinery has been implicated in the genesis of neurodegenerative diseases.
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Neurons: The Axon
The axon attaches to the cell body at a cone-shaped elevation called the axon hillock. The initial part of the axon, closest to the hillock, is known as the initial segment.

