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Updated: Aug 1, 2026

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE
Published on: April 15, 2014
Neuronal plasticity and cellular immunity: shared molecular mechanisms
L M Boulanger1, G S Huh, C J Shatz
1Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. lisa_boulanger@hms.harvard.edu
Abstract:
It is becoming evident that neurons express an unusual number of molecules that were originally thought to be specific to immune functions. One such molecule, class I major histocompatibility complex, is required in the activity-dependent refinement and plasticity of connections in the developing and adult central nervous system, demonstrating that molecules can perform critical roles in both systems. Recent studies reveal striking parallels between cellular signaling mechanisms in the immune and nervous systems that may provide unexpected insights into the development, function, and diseases of both systems.
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