Related Experiment Videos
Nuclear hormone receptors and mouse skin homeostasis: implication of PPARbeta
L Michalik1, B Desvergne, S Basu-Modak
1Institut de Biologie Animale, Université de Lausanne, Bâtiment de Biologie, Lausanne, Switzerland.
Hormone Research
|October 12, 2001
Abstract:
PPARbeta is expressed in the mouse epidermis during fetal development, and progressively disappears from the interfollicular epidermis after birth. Interestingly, its expression is strongly reactivated in the adult epidermis in conditions where keratinocyte proliferation is induced and during wound healing. Data obtained on PPARbeta heterozygous mice reveal that PPARbeta is implicated in the control of keratinocyte proliferation and is necessary for rapid healing of a skin wound.