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[Acetylsalvianolic acid A--a new thromboxane synthetase inhibitor]
1Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|June 1, 1997
Abstract:
With radio thin layer chromatography and autoradiogram, the effect of acetylsalvianolic acid A (ASAA) on 14C-arachidonic metabolism by platelets was studied in vitro. ASAA was found to enhance the formation of PGE2 and PGF2 alpha remarkably while inhibiting the formation of TXB2. However, it showed no effect on the formation of 12-HETE and arachidonic utility rate. Therefore, we deduce that ASAA may be a thromboxane synthetase inhibitor.