Cytoskeleton-dependent transport and localization of mRNA

Messenger RNAs are localized in both somatic and germ cells as a means of focusing the translation of proteins at specific cellular sites. The signals for this lie within the mRNA, and these are recognized by proteins in the cell. The latter appear to be attached via linker proteins to the transport machinery for localization. In some instances it is a myosin motor which translocates along actin microfilaments, and in others kinesin or dynein motors appear to be responsible for driving the movement of mRNA along microtubule substrates. The way that cytoskeleton-based mRNA translocation is regulated is speculated upon.