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Synthesis and characterisation of a new amphotericin B-methoxypoly(ethylene glycol) conjugate
M Sedlák1, V Buchta, L Kubicová
1Department of Organic Chemistry, University of Pardubice, Cs. legií 565, 532 10 Pardubice, Czech Republic. sedlak@upce.cz
Abstract:
The reaction of methoxypoly(ethylene glycol)-4-nitrophenyl carbonate with amphotericin B has been used to prepare a new conjugate of amphotericin B (mPEG-AmB). A preliminary screening of in vitro antifungal activity has suggested that mPEG-AmB possesses a similar effect and a similar spectrum of activity as the conventional amphotericin B formulated with sodium desoxycholate.
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