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Cryptoregiochemical analysis of an unusual bacterial desaturation
1Ottawa-Carleton Chemistry Institute, Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontarion, Canada K1S 5B6.
Bioorganic & Medicinal Chemistry Letters
|October 13, 2001
Abstract:
The cryptoregiochemistry of the cold-induced Delta(5) desaturation of long chain fatty acids, as it occurs in Bacillus subtilis ATCC 23857, has been examined by measuring the individual primary deuterium kinetic isotope effects associated with the C-H bond cleavage at C-5 and C-6. The results point to C-5 as the site of initial oxidation in Delta(5) desaturation.