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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Oligonucleotides containing a lysine residue as 3'-3' junction for alternate strand triple helix formation
G Barone1, L De Napoli, G Di Fabio
1Dipartimento di Chimica, Università di Napoli "Federico II", Via Cinthia, 4, Complesso Universitario di Monte S. Angelo, I-80126, Napoli, Italy.
Abstract:
Oligonucleotides with a 3'-3' inversion of polarity site assured by one lysine residue have been synthesized, characterized and used as third strands in alternate strand triple helix formation. UV melting studies and molecular mechanics calculations have been carried out to investigate the stability and the geometry of these new triplexes.
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