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Related Experiment Videos

Hydrocarbon carcinogens induce p53 activity in normal mouse tissue.

D Stuart1, Q A Khan, R Brown

  • 1CRC Department of Medical Oncology, Alexander Stone Building, Garscube Estate, Switchback Road, Bearsden, G61 1BD, Glasgow, UK. d.stuart@beatson.gla.ac.uk

Cancer Letters
|October 13, 2001
PubMed
Summary

Hydrocarbon carcinogens can damage DNA and evade defenses. This study shows "stealth" carcinogens activate p53 transcriptional activity in normal tissues, similar to known agents.

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Area of Science:

  • Molecular biology
  • Toxicology
  • Carcinogenesis

Background:

  • Certain hydrocarbon carcinogens can damage DNA and bypass cellular defenses.
  • The p53 protein is a key regulator of cellular responses to DNA damage.

Purpose of the Study:

  • To investigate the ability of hydrocarbon carcinogens to induce p53 transcriptional activity in normal tissues.
  • To compare the p53 response to "stealth" carcinogens versus non-stealth agents.

Main Methods:

  • Utilized transgenic mice with a LacZ transgene driven by a p53 response element.
  • Administered putative stealth carcinogens to assess p53 transcriptional activity in normal tissues.

Main Results:

  • Demonstrated that transcriptionally active p53 is induced in normal tissues.

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  • Showed that this induction occurs in an identical manner following exposure to both stealth and non-stealth carcinogens.

    • Conclusions:

    • Hydrocarbon carcinogens, including "stealth" agents, effectively induce p53 transcriptional activity in normal tissues.
    • The cellular defense mechanism involving p53 activation is responsive to a broad range of hydrocarbon carcinogens.