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Relative importance of NF-kappaB p50 in mycobacterial infection

H Yamada1, S Mizuno, M Reza-Gholizadeh

  • 1Department of Molecular Pathology, The Research Institute of Tuberculosis, Tokyo 204-0022, Japan.

Infection and Immunity
|October 13, 2001
PubMed

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NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...