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Updated: Aug 11, 2026
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
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Mycobacterium ulcerans cytotoxicity in an adipose cell model
K M Dobos1, P L Small, M Deslauriers
1Department of Medicine, Emory University School of Medicine, Emory University, Atlanta, Georgia 30303, USA. dobos.karen@mayo.edu
Abstract:
An adipose cell (SW872) model was developed to observe cellular necrosis and apoptosis upon Mycobacterium ulcerans infection and treatment with mycobacterial exudate. Apoptosis was likely due to secreted proteins, while necrosis was likely due to mycolactone. Our data suggest that additional factors in M. ulcerans may be involved in Buruli ulcer pathogenesis.
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