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Naturally occurring Clostridium perfringens nontoxic alpha-toxin variant as a potential vaccine candidate against
H Schoepe1, C Pache, A Neubauer
1Institut für Hygiene und Infektionskrankheiten der Tiere, Justus-Liebig-Universität Giessen, D-35392 Giessen, Germany. Heike.Schoepe@vetmed.uni-giessen.de
Infection and Immunity
|October 13, 2001
Abstract:
Clostridium perfringens mutant strain 121A/91 shows neither enzymatic (phospholipase C) nor hemolytic activity. Nevertheless, the cpa gene and the corresponding alpha-toxin variant are detectable. Vaccination with this genetically constructed alpha-toxin variant, rAT121/91, induces antibodies capable of significantly reducing activities induced by wild-type toxin. Thus, rAT121/91 could be a useful vaccine candidate.