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Reticulum cell sarcoma of lymph node with mixed dendritic and fibroblastic features.

D Jones¹, M Amin, N G Ordonez

¹Division of Pathology and Laboratory MedicineUniversity of Texas-M.D. Anderson Cancer Center, Houston, Texas 77030, USA. dajones@mdanderson.org

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc

|October 13, 2001

Summary

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Cytogenetics as an aid in the diagnosis of lymphomas.

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This study describes a rare aggressive sarcoma in lymph nodes with features of both follicular dendritic cell (FDC) and fibroblastic reticular cell (FRC) sarcoma. The findings suggest a potential link between these cell types in lymph node stromal tumors.

Area of Science:

Oncology
Pathology
Genetics

Background:

Follicular dendritic cell (FDC) sarcoma is a rare tumor originating from FDCs within lymph nodes.
Fibroblastic reticular cells (FRCs) are stromal cells in lymph nodes with poorly defined neoplastic potential.
Understanding the differentiation spectrum of lymph node stromal tumors is crucial for accurate diagnosis and treatment.

Observation:

A case of clinically aggressive reticulum cell sarcoma presented with mixed FDC and FRC features confined to lymph nodes.
Histology showed a multifocal proliferation of epithelioid and spindle cells with high mitotic activity and admixed B-cells.
Ultrastructural analysis revealed features typical of FDC sarcoma, but immunohistochemistry lacked FDC markers (CD21, CD23, CD35).

Findings:

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Cytogenetic analysis identified chromosomal aberrations, including del(X)(p11.4) and add(21)(p11.2).

Gene expression profiling revealed high expression of PDGF receptor-alpha and -beta, metalloproteinases, and CD105, similar to nodal FRCs.

The tumor exhibited an intermediate differentiation profile between FDCs and FRCs.

Implications:

This case expands the known diversity of tumors arising from lymph node stroma.
The findings support a potential relationship and shared origin between FDC and FRC lineages.
Further research into lymph node stromal tumors may reveal new diagnostic markers and therapeutic targets.