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Antineoplastic activity of cannabinoids.

A E Munson, L S Harris, M A Friedman

    Journal of the National Cancer Institute
    |September 1, 1975
    PubMed
    Summary
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    Tetrahydrocannabinol (THC) and cannabinol (CBN) inhibited Lewis lung adenocarcinoma growth and extended survival. Cannabidiol (CBD) did not show significant anti-tumor effects in this study.

    Area of Science:

    • Pharmacology
    • Oncology
    • Cannabinoid Research

    Background:

    • Cannabinoids are compounds found in cannabis with potential therapeutic applications.
    • Lewis lung adenocarcinoma is a common model for studying lung cancer progression and treatment.

    Purpose of the Study:

    • To investigate the effects of various cannabinoids, including delta9-tetrahydrocannabinol (delta9-THC), delta8-tetrahydrocannabinol (delta8-THC), cannabinol (CBN), and cannabidiol (CBD), on Lewis lung adenocarcinoma growth and survival.
    • To evaluate the dose-dependent effects and in vitro activity of these cannabinoids.

    Main Methods:

    • Oral administration of delta9-THC, delta8-THC, CBN, and CBD to mice with Lewis lung adenocarcinoma.
    • Assessment of tumor growth, primary tumor size, and mean survival time.

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  • In vitro experiments using bone marrow and isolated Lewis lung cells to measure the uptake of thymidine and uridine.

    • Main Results:

    • delta9-THC, delta8-THC, and CBN demonstrated dose-dependent inhibition of Lewis lung adenocarcinoma growth and increased mean survival time.
    • CBD showed no significant inhibitory effect on tumor growth or survival.
    • In vitro studies indicated dose-dependent inhibition of cellular uptake by delta9-THC and delta8-THC, with CBD being less effective.

    Conclusions:

    • delta9-THC, delta8-THC, and CBN possess anti-tumor properties against Lewis lung adenocarcinoma in vivo and in vitro.
    • CBD does not exhibit significant anti-cancer activity in this model.
    • Cannabinoids show promise as potential therapeutic agents in oncology, warranting further investigation.