Related Experiment Video
Updated: Jul 7, 2026

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
Published on: July 27, 2017
Interaction of channel-blocking bispyridinium compounds with supported phospholipid layers
A Nelson1, N Geddes, J Tattersall
1School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
Abstract:
The interaction of phospholipid monolayers of dioleoyl phosphatidylcholine (DOPC) on mercury electrodes with bispyridinium compounds is reported in this paper. The interaction is related to the modification of the capacitance-potential plot and in particular of two well defined phase transitions of the phospholipid monolayer. The order of the extent of interaction of the test compounds with the monolayer can be related to their structure and is: P65>Toxogonin>BPE>HS6>TMB4>HI6>BPT>P2S. The penetration of the compound into the monolayer depends on potential. At potentials more negative than the occurrence of the two phase transitions, the test compounds penetrate further and disrupt the monolayers. At more positive potentials this effect is reversed.
Related Concept Videos
Asymmetric Lipid Bilayer
Phosphoinositides and PIPs
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Depolarizing Blockers: Pharmocokinetics

