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Mitomycin C bladder instillation therapy for bladder tumors.

T Mishina, K Oda, S Murata

    The Journal of Urology
    |August 1, 1975
    PubMed
    Summary
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    Topical mitomycin C bladder instillation effectively treated low-stage, low-grade bladder tumors in 76% of patients. This treatment showed minimal side effects, making it a viable option for various bladder tumor cases.

    Area of Science:

    • Urology
    • Oncology

    Background:

    • Bladder tumors present a significant clinical challenge.
    • Effective and minimally invasive treatment options are crucial for managing bladder cancer.

    Purpose of the Study:

    • To evaluate the efficacy and safety of topical mitomycin C (MMC) instillation for bladder tumors.
    • To determine the overall effective rate of this therapeutic approach.

    Main Methods:

    • Fifty patients with bladder tumors received topical bladder instillation of 20 mg mitomycin C.
    • Treatment was administered 3 times weekly for a total of 20 procedures.

    Main Results:

    • Complete tumor disappearance was observed in 44% of patients.
    • Partial tumor disappearance occurred in 32% of patients, resulting in a 76% overall effective rate.

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  • Local bladder reactions were noted in 3 cases, but treatment was completed with minimal interruption.

    • Conclusions:

    • Topical mitomycin C therapy is effective for low-stage and low-grade bladder tumors smaller than 1 cm.
    • The treatment is well-tolerated with no observed hematological abnormalities.
    • Mitomycin C topical therapy is now used for all bladder tumor cases in this study.