Related Experiment Video
Updated: Aug 11, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 19, 2013
[Chronic myeloid leukemia and tyrosine kinase inhibitors]
1Laboratoire de greffe de moelle, université Victor-Segalen, UMR CNRS 5540, 146, rue Léo-Saignat, 33076 Bordeaux, France. Francois-Xavier.Mahon@umr5540.u-bordeaux2.fr
Introduction:
Chronic myeloid leukemia is a myeloproliferative disorder clinically characterised by a triphasic course: after a chronic phase over a median time of 4 years, patients developed an accelerated phase, then a blastic phase, resulting in the patient's death with 3 to 6 months.
Purpose:
During the last past years, progress have been made in the understanding of the molecular mechanism responsible of leukemic growth. This has also provided support for a therapeutic improvement with the appearance of treatment such as tyrosine kinase inhibitors which specifically target the oncoprotein inside the leukemic cells.
Conclusion:
These treatments, such as STI571 or Glivec, are at present in clinical trials, and could be the medicines for the future. Thus, chronic myeloid leukemia is also a model for the development of the new therapeutic drugs.
Related Concept Videos
Inhibition of Cdk Activity
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Receptor Tyrosine Kinases
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

