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Updated: Aug 12, 2026

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

[Dobutrex stress echocardiography: clinical and prognostic value, side effects]

V N Medvedeva, O I Orlova, E L Shashkov

    Terapevticheskii Arkhiv
    |October 16, 2001
    PubMed

    Insights

    Dobutrex echocardiography (DEC) effectively diagnoses myocardial ischemia and aids in prognostication for angina and myocardial infarction. While side effects like tachycardia and arrhythmias can occur, DEC is relatively safe and should be used more in cardiology.

    Area of Science:

    • Cardiology
    • Diagnostic Imaging
    • Clinical Research

    Background:

    • Myocardial ischemia and infarction pose significant health risks.
    • Accurate diagnosis and prognosis are crucial for effective patient management.
    • Atypical cardialgia necessitates reliable diagnostic tools.

    Purpose of the Study:

    • To evaluate the diagnostic value of dobutrex echocardiography (DEC) for myocardial ischemia and viability.
    • To assess DEC's role in prognostication for angina pectoris and myocardial infarction (MI).
    • To determine the safety and side effects of DEC.

    Main Methods:

    • Dobutrex echocardiography (DEC) was performed on 74 patients with unconfirmed diagnoses and 32 patients with known ischemic heart disease.
    • The study focused on patients with risk factors for ischemic heart disease and atypical cardialgia.

    Main Results:

    • DEC demonstrated a 73.6% informative value in diagnosing myocardial ischemia in patients with new-onset atypical cardialgia.
    • The test provides prognostic information, improving treatment strategies for angina of effort and MI.
    • The most frequent side effects were paroxysmal tachycardias (3.76%) and ventricular arrhythmias (6.58%), which were transient and required no specific treatment in 99.1% of cases, indicating relative safety.

    Conclusions:

    • Dobutrex echocardiography is an effective diagnostic tool for myocardial ischemia.
    • DEC aids in prognostication and treatment policy adjustment for angina and MI.
    • The study recommends increased utilization of echocardiography with dobutrex load in clinical cardiology practice.
    Abstract

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