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Therapy and prognosis of hypertension in chronic nephritis
Insights
Antihypertensive therapy improves prognosis in patients with chronic glomerulonephritis (CGN) and hypertension. Propranolol may benefit non-renal failure cases but requires caution in renal failure due to cardiac risks.
Area of Science:
- Nephrology
- Cardiology
- Pharmacology
Background:
- Hypertension is a significant factor in chronic glomerulonephritis (CGN) progression.
- Understanding the impact of blood pressure on renal function and survival in CGN is crucial.
Purpose of the Study:
- To investigate the relationship between blood pressure and renal function in CGN patients.
- To evaluate the effect of antihypertensive therapy on prognosis in hypertensive CGN patients.
- To assess the efficacy and safety of propranolol in CGN with hypertension.
Main Methods:
- Statistical analysis of 421 CGN patients and 253 hypertensive CGN patients.
- Questionnaires sent to 29 medical universities.
- Examination of survival rates in 84 CGN patients.
- Clinical observation of propranolol use in 10 hypertensive CGN patients.
Main Results:
- Antihypertensive therapy significantly impacts prognosis in CGN with hypertension.
- Propranolol demonstrated a hypotensive effect on renal function in hypertensive CGN patients.
- Propranolol may be beneficial for hypertension with a high renin component in non-renal failure CGN.
Conclusions:
- Antihypertensive management is vital for improving outcomes in CGN patients with hypertension.
- Propranolol shows potential for specific hypertensive CGN subgroups but warrants careful administration in patients with renal failure to avoid cardiac complications.
Abstract:
Statistical analysis of the realtion between blood pressure and renal function in 421 patients with CGN, referred to the Second Internal Medicine at Nihon University Hospital, and in 253 Hypertensive patients with CGN by questionaires sent to 29 Medical Universities were investigated. The relationship between survival rate and blood pressure of 84 patients with CGN in Surugadai Nihon University Hospital was also examined. These data show that antihypertensive therapy for CGN with hypertension has an important effect on prognosis. Propranolol was given to 10 hypertensive patients with CGN and hypotensive effect on renal function was observed. Our experience suggests that propranolol may be useful for treating a high renin component in the hypertension with non renal failure, and renal function does not become worse. But in renal failure, propranolol therapy must be used carefully because of inducement to cardiac failure.