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Mortality trend for multiple sclerosis in Italy (1974-1993).

T Tassinari¹, S Parodi, R Badino

¹Azienda Ospedaliera, Ospedale S. Corona, Pietra Ligure, Savona, Italy.

European Journal of Epidemiology

|October 16, 2001

Summary

Multiple sclerosis (MS) mortality in Italy shows a significant increasing trend in the South and Sicily, particularly for females. Northern regions experienced a decrease, suggesting latitude influences MS mortality patterns.

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Area of Science:

Neurology
Epidemiology
Public Health

Background:

Multiple sclerosis (MS) prevalence in Italy is among Europe's highest.
Understanding mortality trends is crucial for disease evolution insights and geographical variations.

Purpose of the Study:

To analyze updated mortality time trends for multiple sclerosis (MS) in Italy.
To investigate geographical and gender-specific differences in MS mortality.

Main Methods:

Standardized mortality ratios (SMR) computed for 1974-1993.
Poisson regression model used for time trend analysis.
Age-adjusted rates calculated using world and Italian population data.

Main Results:

Higher MS mortality rates observed in Northern Italian regions compared to Central/Southern regions and Sicily, especially in females.

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Mortality decreased significantly in Northern Italy for men (-1.15%).

Significant mortality increases observed in Southern Italy and Sicily for both genders (+2.14% males, +3.09% females).

Conclusions:

MS mortality trends vary significantly across Italian regions, with a notable North-South divide.
Latitude appears to influence MS mortality rates.
The increasing trend in Southern Italy warrants further investigation.