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Segmental neurofibromatosis-induced spinal cord compression. Case report
1Department of Neurosurgery, Madurai Medical College, Madurai, India. natmuthu@vsnl.com
Journal of Neurosurgery
|October 16, 2001
Summary
Segmental neurofibromatosis (NF), a rare condition, typically affects peripheral nerves. This case highlights that spinal cord compression can occur in segmental NF, expanding understanding of the disease.
Area of Science:
- Neurology
- Oncology
- Genetics
Background:
- Segmental neurofibromatosis (NF), also known as NF5, is a rare genetic disorder.
- Previously, reported cases exclusively involved peripheral neurofibromas.
Observation:
- A 40-year-old woman presented with a 6-month history of intercostal neuralgia.
- Clinical examination revealed mild lower extremity weakness and T-9 dermatome sensory changes.
- Magnetic resonance imaging identified three neurofibromas in the T-9 region.
Findings:
- The neurofibromas causing spinal cord compression were surgically excised.
- Postoperative resolution of neuralgic pain was achieved.
- This case demonstrates spinal cord involvement in segmental NF, challenging previous assumptions.
Implications:
- This case expands the known clinical spectrum of segmental neurofibromatosis.
- It underscores the importance of considering spinal involvement in segmental NF diagnosis.
- Further research is warranted to understand the mechanisms and prevalence of spinal cord compression in this rare condition.