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Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.

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Evaluation of the Computer-assisted Speech Perception Assessment Test (CASPA).

C L Mackersie¹, A Boothroyd, D Minniear

¹Department of Communicative Disorders, San Diego State University, California 92182, USA.

Journal of the American Academy of Audiology

|October 16, 2001

Summary

The Computer-Assisted Speech Perception Assessment (CASPA) Test shows a small practice effect, which can be managed with a brief warm-up list. Some word lists demonstrated higher scores, suggesting minor interlist differences.

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Area of Science:

Audiology
Speech-Language Pathology
Psychometrics

Background:

The Computer-Assisted Speech Perception Assessment (CASPA) Test is a tool used to evaluate speech perception.
Understanding interlist equivalency and practice effects is crucial for accurate assessment results.
Previous research has not fully detailed these specific effects for the CASPA Test's recorded stimuli.

Purpose of the Study:

To evaluate interlist equivalency of recorded word lists for the CASPA Test.
To assess short-term practice effects associated with repeated administration of CASPA Test lists.
To determine the impact of these factors on the reliability of speech perception scores.

Main Methods:

Twenty lists of 10 consonant-vowel-consonant words were administered to 20 normal-hearing adults.
Stimuli were presented at 50 dB SPL (Leq) amidst spectrally matched steady-state noise (55 dB SPL Leq).
Phoneme recognition scores were analyzed to identify practice effects and interlist differences.

Main Results:

A small practice effect was observed, with scores increasing from the first to subsequent lists.
Four specific lists (3, 6, 7, and 16) showed significantly higher scores (approx. 10 percentage points) than the others.
Excluding interlist differences reduced the 95% confidence interval for a single list score from 18.4 to 16.1 percentage points.

Conclusions:

A single practice list can mitigate the observed short-term practice effect in the CASPA Test.
While interlist differences are small, excluding specific lists (3, 6, 7, 16) may enhance score precision for some clinicians.
The CASPA Test demonstrates good reliability, with minor adjustments improving score interpretation.