Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glucose-induced insulin hypersecretion in lipid-infused healthy subjects is associated with a decrease in plasma

C Magnan1, C Cruciani, L Clément

  • 1Université Paris 7, Centre National de la Recherche Scientifique ESA 7059, 2 place Jussieu, 75251 Paris cedex 05, France. magnan@paris7.jussieu.fr

The Journal of Clinical Endocrinology and Metabolism
|October 16, 2001
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A pilot study of a sexual health workshop for oncology staff: feasibility, impact, and gaps in addressing young adult breast cancer survivorship needs.

Journal of cancer survivorship : research and practice·2026
Same author

[Emergency room visits for asthma and the reported outcomes: The PASS survey by the CRISALIS network].

Revue des maladies respiratoires·2025
Same author

What's new in the diagnosis and treatment of human brucellosis?

Infectious diseases now·2025
Same author

Gynecologic cancer survivor preferences for provider communication regarding sexual health after treatment: a qualitative study.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2024
Same author

Academic clinician frontline-worker wellbeing and resilience during the COVID-19 pandemic experience: Were there gender differences?

Preventive medicine reports·2023
Same author

Baseline [<sup>18</sup>F]FDG PET features are associated with survival and toxicity in patients treated with CAR T cells for large B cell lymphoma.

European journal of nuclear medicine and molecular imaging·2023

A 48-hour triglyceride infusion in healthy men led to increased insulin secretion in response to glucose. This effect may be linked to a reduction in sympathetic nervous system activity, indicated by lower catecholamine levels.

Area of Science:

  • Endocrinology
  • Metabolic Research
  • Physiology

Background:

  • Elevated free fatty acids (FFAs) can impact glucose metabolism and insulin sensitivity.
  • Sympathetic nervous system activity plays a role in regulating glucose homeostasis and insulin secretion.

Purpose of the Study:

  • To investigate the effect of a 48-hour triglyceride infusion on glucose-stimulated insulin secretion in healthy men.
  • To assess changes in sympathetic tone, measured by catecholamine levels, during triglyceride infusion.

Main Methods:

  • Twenty healthy male volunteers received either a triglyceride/heparin or saline infusion for 48 hours.
  • Insulin secretion was evaluated using intravenous glucose injection followed by a hyperglycemic clamp.
  • Plasma and urinary catecholamine concentrations (norepinephrine) were measured to estimate sympathetic activity.

Related Experiment Videos

Main Results:

  • Triglyceride infusion significantly increased plasma FFAs, insulin, and C-peptide levels compared to saline.
  • Plasma and urinary norepinephrine levels were lower after triglyceride infusion, suggesting decreased sympathetic tone.
  • Glucose challenge elicited a more pronounced insulin and C-peptide response following triglyceride infusion.

Conclusions:

  • A 48-hour lipid infusion in healthy individuals results in basal hyperinsulinemia.
  • Exaggerated insulin secretion in response to glucose after lipid infusion may be partly mediated by reduced sympathetic nervous system activity.