Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hereditary colorectal carcinomas - reflection on preventive surgery].

S Pistorius1, H K Schackert, H D Saeger

  • 1Klinik und Poliklinik für Viszeral, Thorax und Gefässchirurgie, Universitätsklinikum Carl Gustav Carus, TU Dresden, Germany. spisto2522@aol.com

Onkologie
|October 16, 2001
PubMed
Summary

Hereditary colorectal cancers like Nonpolyposis Colorectal Cancer (HNPCC) require tailored surveillance. Subtotal colectomy may be indicated for first colon cancers in HNPCC patients due to high metachronous cancer rates.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum: "Real time breast microwave radar image reconstruction using circular holography: A study of experimental feasibility" [Med. Phys. 38, 5420-5431 (2011)].

Medical physics·2017
Same author

Poster - Thur Eve - 14: The effect of fluence and detector size on image quality in multi-projection compton scatter tomography.

Medical physics·2017
Same author

Poster - Thurs Eve-33: Initial implementation of a novel, measurement-based IMRT QA method.

Medical physics·2017
Same author

Sci-Sat AM(1): Imaging-05: Analytical scatter estimation for cone-beam computed tomography.

Medical physics·2017
Same author

[Complex pelvic and sarcoma surgery with vascular replacement].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2015
Same author

(13)C-Leucine-tracer-technique for in-vivo measurement of amino acids' metabolism by human colon carcinomas.

Amino acids·2013

Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Clinical Genetics

Context:

  • Nonpolyposis Colorectal Cancer (HNPCC) is the most common hereditary colorectal cancer (5%), distinct from Familial Adenomatous Polyposis (FAP, 1%).
  • Identifying pathogenic germline mutations is crucial for personalized surveillance strategies in hereditary colorectal cancers.
  • Current surgical standards for HNPCC are less defined than for FAP, lacking robust evidence for prophylactic interventions.

Purpose:

  • To review current evidence and provide recommendations for surgical management of hereditary colorectal cancers, particularly HNPCC.
  • To highlight the rationale for extended resection in HNPCC, considering metachronous cancer rates and tumor progression.
  • To emphasize the need for prospective clinical trials to establish definitive surgical guidelines for HNPCC.

Related Experiment Videos

Summary:

  • In HNPCC, prophylactic colectomy before cancer onset is not advised. However, a high rate of metachronous colorectal cancers (40-45% over 10 years) and rapid progression support extended resection for the first colorectal carcinoma.
  • For first colon cancers in HNPCC, subtotal colectomy is suggested. Proctocolectomy or restorative proctocolectomy may be considered for lower rectal carcinomas.
  • Management of hereditary colorectal cancers, including counselling, molecular diagnosis, and surgery, should occur in specialized interdisciplinary centers.

Impact:

  • This review aims to guide surgical decision-making in HNPCC, potentially improving patient outcomes by addressing the high risk of metachronous disease.
  • Recommendations for subtotal colectomy in HNPCC could lead to more effective treatment strategies, reducing the incidence of subsequent cancers.
  • Establishing interdisciplinary centers for hereditary colorectal cancer care ensures comprehensive management and facilitates future research through prospective trials.