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[A surveillance study on penicillin-resistant Streptococcus pneumoniae in China]
1Institute of Clinical Pharmacology, First Hospital of Beijing Medical University, Beijing 100034.
Insights
Penicillin-resistant Streptococcus pneumoniae strains were identified in China, with a 4% resistance rate. This highlights significant cross-resistance issues in the country.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Research
Context:
- Pediatric respiratory tract infections are common.
- Streptococcus pneumoniae is a significant pathogen.
- Antibiotic resistance is a growing global concern.
Purpose:
- To determine the prevalence of penicillin-resistant Streptococcus pneumoniae (PRSP).
- To assess the antibiotic resistance rates of S. pneumoniae isolates in China.
Summary:
- A study of 989 pediatric patients in China identified Streptococcus pneumoniae isolates.
- Antibiotic susceptibility testing revealed a 4% penicillin resistance rate.
- High resistance rates were observed for erythromycin (54%), clarithromycin (52%), and tetracycline (100%).
Impact:
- The findings confirm the presence of PRSP in China.
- Significant cross-resistance among various antibiotics was noted.
- This underscores the need for ongoing surveillance and antimicrobial stewardship.
Objectives:
To find out if there are penicillin-resistant Streptococcus pneumoniae and the resistance rate in China.
Methods:
989 pediatric patients with respiratory tract infections aged from 6 months to 3 years from two pediatric units were enrolled. Perthroat swabs were immediately streaked onto blood agar plates and incubated overnight. Pneumococci were identified and isolated. Antibiotic susceptibility was assessed by the disk diffusion method and MIC determination according to Protocol and NCCLS.
Results:
Of the 51 Streptococcus pneumoniae isolates, 5 strains had zones > or = 20 mm. Two of the 5 strains had penicillin MICs > or = 0.1 mg/L (2 and 4 mg/L) and considered to be fully resistant to penicillin(4%). The resistance rate to ceftriaxone and cefotaxime was 0 and 4% respectively. For the other 10 antimicrobial agents, the resistance rates were as follows: ampicillin 12%, piperacillin 26%, furbenicillin 14%, cefuroxime 6%, erythromycin 54%, clarithromycin 52%, meleumycin 64%, roxithromycin 52%, chloramphenicol 32%, and tetracycline 100%.
Conclusions:
The study suggested that penicillin resistant Streptococcus Pneumoniae strains also exist, and the cross-resistance is a significant phenomenon in China.