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[Gene diagnosis of X linked retinitis pigmentosa by linkage analysis]
1Human Genome Laboratory, Institute of Genetics, Fudan University, Shanghai 200433.
Zhonghua Yi Xue Za Zhi
|October 17, 2001
Abstract
Objective:
To establish a gene diagnosis method for X linked retinitis pigmentosa (XLRP).
Methods:
Ten microsatellite markers were selected from the region where the RP2 and RP3 gene may be located at Xp21.1-p11.23. Haplotype analysis for XLRP pedigrees was used to determine the chromosome region which is RP related and whether this region was carried by the individuals we want to detect.
Results:
The young female who is the RP carrier or the young boy who is the pre-symptom RP patient could be determined this way in 4 XLRP family.
Conclusion:
Haplotype analysis for XLRP Pedigrees is useful.