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[Hemorrhagic diarrhea with competing etiologies].

N Jacobsen1, B Olesen, O M Nielsen

  • 1Hillerød Sygehus, organkirurgisk afdeling A. njac@dadlnet.dk

Ugeskrift for Laeger
|October 17, 2001
PubMed
Summary

A case of pseudomembranous colitis in a 41-year-old woman was linked to a combination of E. coli O103:H2 infection, ergotamine overdose, and estrogen-containing contraceptives, causing bloody diarrhea.

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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Toxicology

Background:

  • Bloody diarrhea is a significant symptom requiring thorough etiological investigation.
  • Pseudomembranous colitis can be caused by various factors, including infections and medications.

Observation:

  • A 41-year-old woman presented with bloody diarrhea.
  • Histological examination following a hemicolectomy revealed pseudomembranous colitis.
  • The patient was infected with verotoxin-producing Escherichia coli O103:H2.

Findings:

  • The patient had also taken an overdose of ergotamine and was using an estrogen-containing contraceptive.
  • While each factor individually can cause bloody diarrhea, their combination is proposed as the unique etiology in this case.

Implications:

  • This case highlights the potential for synergistic effects between infectious agents and pharmaceutical substances in causing severe gastrointestinal conditions.
  • Clinicians should consider polypharmacy and potential drug-herb interactions in patients presenting with unexplained bloody diarrhea.
  • Further research into the interaction between E. coli, ergotamine, and oral contraceptives may be warranted.

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