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[Immunophenotype and P-glycoprotein expression in CD7 positive adult acute myeloid leukemia]
1First Affiliated Hospital, Suzhou Medical College, Jiangsu Institute of Hematology, Suzhou 215006.
Objective:
To study the immunophenotype and P-glycoprotein expression in CD7 positive adult acute myeloid leukemia (CD7+ AML).
Methods:
Morphology, P-glycoprotein, cytogenetics and immunophenotype were examined in 30 previously untreated CD7+ AML patients.
Results:
The CD7 positive rate was 11.4% in 262 AML patients. CD7+ AML patients had a significantly higher incidence of peripheral leukocytosis and blasts and FAB M1 subtype and were associated with CD34 and P-glycoprotein expression. 42.3% of CD7+ AML achieved complete remission with a median remission duration of 4 months, and a median time to CR of 48 days.
Conclusion:
Patients with CD7+ AML are usually CD34 and P-glycoprotein positive. These patients had a lower CR rate and a shorter remission duration.