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[Leukocyte glucocorticoid receptor and its mRNA levels in leukemia patients]
1Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai 200433.
Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi
|October 17, 2001
Abstract
Objective:
To explore factors for differentiating non-Hodgkin's lymphoma cell leukemia (NHLCL) and acute lymphoblastic leukemia (ALL).
Methods:
Leukocyte glucocorticoid receptor (GR) and GR mRNA levels were measured in 22 NHLCL, 18 ALL, 10 chronic lymphocytic leukemia (CLL) patients and 6 healthy subjects by using radio-ligand binding assay and molecular hybridization using GR cDNA as the probe.
Results And Conclusions:
The leukocyte GR and GR mRNA levels were significantly different between NHLCL and ALL(P < 0.01), and could be used as parameters for differential diagnosis of these two types of leukemia.