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Updated: Sep 29, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
[The effect of human cytomegalovirus on human marrow granulocyte/macrophage progenitor]
1Third Teaching Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510630.
Objective:
To investigate whether the suppression of CFU-GM is caused directly by human cytomegalovirus(HCMV).
Methods:
The effect of HCMV AD 169 strain on CFU-GM growth was assayed in vitro and HCMV AD 169 DNA in CFU-GM was detected by in situ PCR(ISPCR).
Results:
Significant inhibition of CFU-GM was observed when HCMV AD 169 containing fluid was diluted to 2 x 10(5) pfu/ml and 2 x 10(6) pfu/ml (P < 0.01). The suppression was in a dose-dependent fashion. HCMV AD 169-DNA was detected by ISPCR on the nuclear of CFU-GM.
Conclusion:
HCMV might cause suppression of CFU-GM growth by direct infection.
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