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Updated: Oct 4, 2026
Ultrasonography in Experimental Reproductive Investigations on Rats
Published on: December 2, 2017
[Effect of yuanhua on isolated uterine strips in unpregnant rats]
Objective:
To explore the mechanism on the effect of Yuanhua on the contractile activity of isolated uterine strips in rats under artificial oestrum.
Method:
Isolated strips were suspended in a tissue chamber in which Yuanhua was added with some antagonists of inhibitors or without.
Result:
Yuanhua could excite the uterine smooth muscle strips in a dose-dependent manner, but atropine, phentolamine, hexamethonium and diphenhydramine could not inhibit this exciting action. This exciting effect could be inhibited completely by verapamil and decreased by indomethacin(inhibitor of prostaglandin synthase).
Conclusion:
The exciting effect of Yuanhua on un-pregnant rats in vitro might be related to an action on the cell membrane Ca2+ channel as well as to a partial stimulation of synthesis and release of PG.
