Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Are certain diuretics also anticonvulsants?

D C Hesdorffer1, J P Stables, W A Hauser

  • 1Gertrude H. Sergievsky Center, Columbia University, New York, NY 10032, USA. dch5@columbia.edu

Annals of Neurology
|October 17, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resting-state functional connectivity and cognitive impairment after COVID-19 infection: Evidence from a large-scale fMRI study.

European psychiatry : the journal of the Association of European Psychiatrists·2026
Same author

Utility of EEG Activation Procedures in Epilepsy: A Population-Based Study.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2017
Same author

Quantitative Evaluation of Medial Temporal Lobe Morphology in Children with Febrile Status Epilepticus: Results of the FEBSTAT Study.

AJNR. American journal of neuroradiology·2016
Same author

Can the predictive value of epileptiform electroencephalography abnormalities be assessed by a meta-analysis?

European journal of neurology·2015
Same author

Comparative safety of antiepileptic drugs during pregnancy.

Neurology·2012
Same author

Accuracy of family history information on epilepsy and other seizure disorders.

Neurology·2011
Same journal

AQP4 and MOG Characterize the Autoantibody Landscape of Checkpoint Blockade-Induced Optic Neuritis.

Annals of neurology·2026
Same journal

Five Issues of Artificial Intelligence in Science: Sailing the Ship of Theseus.

Annals of neurology·2026
Same journal

Reply to "Clinical Value of Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysm".

Annals of neurology·2026
Same journal

Clinical Value of Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysm.

Annals of neurology·2026
Same journal

Imaging of Neurovascular Compression in Thoracic Outlet Syndrome.

Annals of neurology·2026
Same journal

Reply to "Methodological Challenges in Interpreting SAA-Defined Imaging Subgroups in Parkinson's Disease".

Annals of neurology·2026
See all related articles

Diuretic use, including thiazides and furosemide, may protect against seizures. Both medications showed anticonvulsant activity in animal models and epidemiological studies, suggesting potential for seizure control.

Area of Science:

  • Neurology
  • Pharmacology
  • Epidemiology

Background:

  • Previous studies indicated diuretic use is protective against first unprovoked seizures in adults.
  • Emerging animal research suggests specific diuretics possess anticonvulsant properties.

Purpose of the Study:

  • To investigate the anticonvulsant potential of current diuretic use in older adults.
  • To evaluate chlorthiazide and furosemide for seizure protection in animal epilepsy models.

Main Methods:

  • A population-based, case-control study was conducted in older adults.
  • Animal models (mice and rats) were used to test chlorthiazide and furosemide against electroshock-induced seizures.

Main Results:

  • Diuretic use was associated with a reduced risk of epilepsy (OR = 0.62).

Related Experiment Videos

  • Thiazide use showed a significant protective effect (OR = 0.53), and furosemide suggested protection (OR = 0.44).
  • Both chlorthiazide and furosemide demonstrated dose-dependent seizure suppression in animal models with low toxicity.

    • Conclusions:

    • Chlorthiazide and furosemide exhibit protective effects against unprovoked seizures.
    • Their low toxicity and cost warrant further investigation in clinical trials for seizure management.