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Related Experiment Videos

[Stem cells in adults].

O J Borge1, S Funderud

  • 1Avdeling for immunologi Det Norske Radiumhospital 0310 Oslo.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|October 18, 2001
PubMed
Summary
This summary is machine-generated.

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Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2002
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Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity.

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Self-renewal of multipotent long-term repopulating hematopoietic stem cells is negatively regulated by Fas and tumor necrosis factor receptor activation.

The Journal of experimental medicine·2001
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A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes.

Blood·1999
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Distinct requirements for optimal growth and In vitro expansion of human CD34(+)CD38(-) bone marrow long-term culture-initiating cells (LTC-IC), extended LTC-IC, and murine in vivo long-term reconstituting stem cells.

Blood·1999

Adult stem cells exhibit plasticity, differentiating into various cell types beyond their origin tissue. While promising for future medicine, further research is needed to confirm clinical applications in humans.

Area of Science:

  • Biomedical Science
  • Cell Biology
  • Regenerative Medicine

Context:

  • Adult stem cells (ASCs) are multipotent cells found in various tissues.
  • Recent research highlights the remarkable plasticity of ASCs.
  • Understanding ASC plasticity is crucial for advancing cell-based therapies.

Purpose:

  • To review and summarize the observed plasticity of adult stem cells.
  • To explore the potential of ASCs to differentiate into diverse cell types.
  • To assess the current state of research regarding ASC differentiation capabilities.

Summary:

  • Adult stem cells can terminally differentiate into cell types distinct from their tissue of origin.
  • Examples include bone marrow cells generating liver, nerve, heart, and skeletal muscle cells.

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  • This demonstrates a significant potential for therapeutic applications.

    • Impact:

    • Current evidence primarily comes from animal models, indicating a proof-of-principle.
    • Extensive research is required before clinical application in human medicine.
    • Findings offer cautious optimism for the future of regenerative medicine and ASC-based therapies.