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Pharmacist-managed hypertension therapy conversion.

J K Yanchick1

  • 1Drug Therapy Monitoring Unit, Reynolds Army Community Hospital, Department of Pharmacy, Building 4300, Fort Sill, OK 73503-6300, USA.

Military Medicine
|October 18, 2001
PubMed
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Switching 543 hypertension patients from nifedipine GITS to amlodipine significantly improved blood pressure control. This transition also achieved substantial cost savings, reducing annual medication expenses by $47,844.

Area of Science:

  • Pharmacology
  • Cardiovascular Medicine
  • Health Economics

Background:

  • Hypertension treatment costs are a significant burden on healthcare systems.
  • Nifedipine gastrointestinal therapeutic system (GITS) is a common antihypertensive medication.
  • Optimizing treatment regimens can improve patient outcomes and reduce expenditures.

Purpose of the Study:

  • To evaluate the impact of switching hypertensive patients from nifedipine GITS to amlodipine.
  • To assess improvements in blood pressure control post-switch.
  • To quantify the cost savings associated with this therapeutic change.

Main Methods:

  • A cohort of 543 hypertensive patients was switched from nifedipine GITS to amlodipine.
  • An educational program was implemented for healthcare providers and patients.

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  • Blood pressure was monitored, and medication dosages were adjusted as needed.
  • Annual medication costs were compared before and after the switch.

    • Main Results:

    • Amlodipine therapy significantly reduced blood pressure in patients.
    • Mean systolic blood pressure decreased from 140/82 to 130/76 mm Hg.
    • Annual primary antihypertensive therapy costs decreased by $47,844, a 27% reduction.

    Conclusions:

    • Conversion from nifedipine GITS to amlodipine enhances blood pressure control.
    • This switch leads to significant cost savings in antihypertensive medication.
    • The study demonstrates a cost-effective strategy for managing hypertension.