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Related Experiment Videos

Surfactant protein D (SP-D) and systemic scleroderma (SSc).

M Maeda1, Y Ichiki, Y Aoyama

  • 1Departament of Dermatology, Gifu Prefectural Hospital, Japan.

The Journal of Dermatology
|October 18, 2001
PubMed
Summary

Serum levels of surfactant protein D (SP-D) are elevated in systemic scleroderma (SSc) and correlate with pulmonary fibrosis severity. Higher SP-D levels in SSc patients may indicate worse lung involvement in collagen diseases.

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Area of Science:

  • Pulmonary Medicine
  • Rheumatology
  • Biochemistry

Background:

  • Collagen diseases encompass a range of autoimmune conditions affecting connective tissues.
  • Systemic scleroderma (SSc) is a significant collagen disease often associated with pulmonary complications.
  • Surfactant protein D (SP-D) is a pulmonary collectin with roles in innate immunity and lung homeostasis.

Purpose of the Study:

  • To measure serum SP-D levels in patients with various collagen diseases.
  • To investigate the correlation between serum SP-D levels and pulmonary fibrosis and function in these patients.
  • To compare SP-D levels between different collagen disease subtypes and controls.

Main Methods:

  • Serum SP-D levels were measured in 110 patients with collagen diseases (SSc, SSD, SLE, Sjs, DM, RA) and 109 controls with dermatitis.

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  • Correlation analyses were performed between SP-D levels and pulmonary fibrosis severity, vital capacity (%DLco), and forced expiratory volume (FEV1.0%).
  • SP-D levels were compared between disease groups, disease subtypes (e.g., SSc Barnett types), and antibody profiles.

    • Main Results:

    • Serum SP-D levels were significantly higher in SSc and Scleroderma Spectrum Disorders (SSD) compared to other collagen diseases (SLE, DM, Sjs, RA) and dermatitis controls (p<0.005).
    • Elevated SP-D levels were observed in SSc patients with Barnett type III and those with anti-topoisomerase I antibodies.
    • A significant positive correlation was found between SP-D levels and pulmonary fibrosis severity, and a negative correlation with vital capacity and %DLco.

    Conclusions:

    • Serum SP-D levels are elevated in systemic scleroderma (SSc) and correlate with pulmonary fibrosis severity and lung function impairment.
    • SP-D may serve as a potential biomarker for pulmonary involvement in SSc and related collagen vascular diseases.
    • Plasma SP-D levels were higher than serum levels in the collagen disease group, suggesting potential compartment-specific roles.