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Related Experiment Videos

Pathological abnormalities in the normal-appearing white matter in multiple sclerosis.

I V Allen1, S McQuaid, M Mirakhur

  • 1School of Biology and Biochemistry, Medical Biology Centre, Queen's University of Belfast, Northern Ireland, UK.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|October 18, 2001
PubMed
Summary

Multiple sclerosis (MS) normal-appearing white matter (NAWM) shows abnormalities linked to disability. Microglial activation may signal underlying myelin and axonal damage in MS NAWM.

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Area of Science:

  • Neuroscience
  • Pathology
  • Immunology

Background:

  • Multiple sclerosis (MS) is characterized by white matter abnormalities, even in areas appearing normal on MRI (NAWM).
  • These NAWM abnormalities correlate with disability but their pathological basis remains unclear.
  • Early MS lesions form in NAWM before blood-brain barrier breakdown.

Purpose of the Study:

  • To investigate the pathological basis of NAWM abnormalities in MS.
  • To determine if microglial activation is a marker for oligodendrocyte/myelin and axonal pathology in MS NAWM.

Main Methods:

  • Analysis of MS NAWM samples.
  • Assessment of microglial activation using phenotype and HLA-DR positivity.
  • Correlation of microglial activation with oligodendrocyte/myelin and axonal pathology.

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Main Results:

  • A pilot study indicated microglial activation in 90% of MS NAWM cases.
  • The current study hypothesizes microglial activation as a marker for pathology in MS NAWM.

Conclusions:

  • Microglial activation is frequent in MS NAWM.
  • Further research is needed to confirm microglial activation as a marker for underlying pathology and its role in MS progression.