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Clozapine: diabetes mellitus, weight gain, and lipid abnormalities
1Department of Psychiatry and the Schizophrenia Program, Massachusetts General Hospital, Boston, USA. dchenderson@partners.org
Abstract:
Clozapine remains the most effective agent for treatment-resistant patients with schizophrenia. Recently, treatment with clozapine has been linked to a number of metabolic disturbances, including weight gain, diabetes mellitus, and serum lipid abnormalities. Despite the potential risks of medical morbidities, clozapine continues to have a major role in the care of treatment-resistant patients with schizophrenia. This article discusses the diagnosis and significance of the above metabolic abnormalities and potential mechanisms for these abnormalities as well as recommendations for monitoring and treatment.
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