Related Experiment Videos
Granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid
N Tomita1, H Kanamori, H Fujita
1Department of Hematology , Fujieda Municipal General Hospital, Shizuoka, 426-8677, Japan. cavalier@ch-yamate.dienet.com
Anti-Cancer Drugs
|October 18, 2001
Abstract:
We report the first case of granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid (ATRA) in a patient with acute promyelocytic leukemia (APL). Acute renal failure during treatment with ATRA has been previously reported as a part of an ATRA syndrome or a thrombotic complication of a hypercoagulable state. This case indicates an alternative mechanism of acute renal failure occurring during ATRA therapy.