Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transplantation hematopoiesis.

M Podestà1

  • 1Dipartimento di Emato-Oncologia, Ospedale San Martino, Genova, Italy. marinapodesta@smartino.ge.it

Current Opinion in Hematology
|October 18, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improved Transition Management of Adolescents and Young Adults With Allergy and/or Asthma: An EAACI Task Force Report on a Follow-Up European Survey.

Allergy·2025
Same author

Design of a Thomson scattering diagnostic for the SMall Aspect Ratio Tokamak (SMART).

The Review of scientific instruments·2024
Same author

Perturbed Ion Temperature and Toroidal Flow Profile Measurements in Rotating Neoclassical Tearing Mode Magnetic Islands.

Physical review letters·2024
Same author

Evidence of Electron Heating by Alpha Particles in JET Deuterium-Tritium Plasmas.

Physical review letters·2023
Same author

Lost alpha Faraday cup foil noise characterization during Joint European Torus plasma post-processing analysis.

The Review of scientific instruments·2022
Same author

Brachytherapy treatment verification using gamma radiation from the internal treatment source combined with an imaging panel-a phantom study.

Physics in medicine and biology·2021

Hematopoietic stem cells (HSCs) rebuild blood systems post-transplant. Despite initial stress and telomere shortening, HSCs eventually restore normal blood cell production, even in defective microenvironments.

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Transplantation Immunology

Background:

  • Hematopoietic reconstitution post-transplantation depends on stem cell migration to the bone marrow.
  • Initial engraftment involves high stem cell proliferation, leading to telomere shortening.

Purpose of the Study:

  • To elucidate the behavior of hematopoietic stem cells during and after transplantation.
  • To understand the long-term functional capacity of the stem cell reservoir in transplant recipients.

Main Methods:

  • Analysis of stem cell behavior during the engraftment phase.
  • Assessment of telomere length dynamics in stem cells and progeny.
  • Evaluation of hematopoietic microenvironment and stem cell reservoir status post-transplantation.

Related Experiment Videos

Main Results:

  • Stem cell proliferation and telomere shortening occur during initial engraftment.
  • Progenitor cell replication stabilizes, and stem cells return to quiescence upon full reconstitution.
  • Despite prolonged defects, donor HSCs typically achieve polyclonal hematopoiesis and sustained normal counts.

Conclusions:

  • The hematopoietic system in transplant recipients, while initially stressed, demonstrates resilience.
  • Donor-derived stem cells can overcome defective microenvironments to restore long-term hematopoietic function.