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Published on: February 3, 2012
Autoimmune hepatitis associated with coagulation disorders and immunethyreopathy
D Benten1, A Widjaja, M von Depka
1Department of Gastroenterology-Heptaology, Hannover Medical School, Germany.
Zeitschrift Fur Gastroenterologie
|October 18, 2001
Summary
This case highlights a rare combination of autoimmune hepatitis and antiphospholipid antibodies in a patient with Factor V Leiden mutation, leading to thrombosis and miscarriage. Increased vigilance for thrombophilia is crucial in autoimmune hepatitis patients.
Area of Science:
- Immunology
- Hematology
- Hepatology
Background:
- Autoimmune hepatitis and autoimmune thyroiditis are common autoimmune disorders.
- Antiphospholipid syndrome is associated with thrombophilia and pregnancy complications.
- Factor V Leiden mutation causes activated protein C (APC) resistance, a risk factor for thrombosis.
Observation:
- A 42-year-old female presented with autoimmune hepatitis type I and autoimmune thyroiditis.
- She had homozygous Factor V Leiden mutation and antiphospholipid antibodies.
- This led to recurrent deep vein thromboses and miscarriages.
Findings:
- The patient exhibited an unusual coexistence of autoimmune hepatitis, antiphospholipid antibodies, and Factor V Leiden mutation.
- This combination resulted in significant thrombotic events and obstetric complications.
- Few cases report the co-occurrence of autoimmune hepatitis and antiphospholipid antibodies, often presenting as antiphospholipid syndrome.
Implications:
- The shared HLA patterns suggest that autoimmune hepatitis and antiphospholipid antibodies may co-occur more frequently than reported.
- Screening for thrombophilia, including Factor V Leiden mutation and antiphospholipid antibodies, is recommended for patients with autoimmune hepatitis.
- Early detection and management of thrombophilia can prevent severe complications like deep vein thrombosis and miscarriages.
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