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Cowden's disease with vocal fold involvement.
1Division of Head and Neck/Plastic and Reconstructive Surgery, Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR. edwardto@cuhk.edu.hk
Ear, Nose, & Throat Journal
|October 19, 2001
Summary
This case report details Cowden's disease, a rare genetic disorder, in a 47-year-old man. It highlights the first documented instance of vocal fold involvement in this condition, emphasizing its varied mucocutaneous manifestations.
Area of Science:
- Otolaryngology
- Dermatology
- Genetics
Background:
- Cowden's disease is a rare hereditary disorder.
- It is characterized by oropharyngeal fibrosis and multiple hamartomas.
- These hamartomas have the potential for malignant transformation.
Observation:
- A 47-year-old male patient presented with fibrotic lesions on the left vocal fold.
- The patient also exhibited extensive papillomatous lesions on the lips, tongue, pharyngeal wall, axillae, and buttocks.
- Histopathologic examination confirmed the mucocutaneous lesions were diagnostic of Cowden's disease.
Findings:
- This case represents the first reported instance of Cowden's disease affecting the vocal fold.
- The findings underscore the diverse mucocutaneous presentations of Cowden's disease.
Implications:
- Early diagnosis and management of Cowden's disease are crucial due to malignant potential.
- Vocal fold involvement should be considered in the differential diagnosis of unexplained laryngeal lesions.
- This case expands the known spectrum of Cowden's disease manifestations.