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Synthesis of cis- and trans-5,8-dihydroxy-5,6,7,8-tetrahydro-1,4-naphthoquinone
S Arima1, Y Yamada Konda, K Takeda
1School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan. arimas@pharm.kitasato-u.ac.jp
Chemical & Pharmaceutical Bulletin
|October 19, 2001
Abstract:
Cis- and trans-5,8-dihydroxy-5,6,7,8-tetrahydro-1,4-naphthoquinone (1a, 1b) were for the first time synthesized from 5,8-dihydroxy-1,4-naphthoquinone (naphthazazine) (6) as a starting material and racemic triol (3) was first synthesized from 7. The configuration of 1a was determined by X-ray analysis.