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Published on: September 12, 2019
An alpha-fetoprotein-producing hepatoid adenocarcinoma of the endometrium
S F Adams1, S D Yamada, A Montag
1Department of Obstetrics and Gynecology, University of Chicago, Illinois 60637, USA.
Background:
Hepatoid adenocarcinomas are tumors that arise outside the liver but resemble hepatic tissue and produce alpha-fetoprotein. These neoplasms have been described in many locations, including the lung, gastrointestinal tract, and urogenital tract, and have been associated with a poor prognosis. Two previously reported cases of hepatoid adenocarcinoma of the endometrium described aggressive tumors that were unresponsive to multiple forms of therapy.
Case:
We report a case of an alpha-fetoprotein-producing hepatoid adenocarcinoma of the endometrium that was successfully treated with surgery and adjuvant chemotherapy.
Conclusion:
Eight years after therapy, the patient is alive with no evidence of disease, suggesting that cytoxan, adriamycin, and cis-platinum are active agents in this unusual entity.
